Richard E Gilbert Selected Research

SB-267268

4/2006

SB-267268, a nonpeptidic antagonist of alpha(v)beta3 and alpha(v)beta5 integrins, reduces angiogenesis and VEGF expression in a mouse model of retinopathy of prematurity.

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Richard E Gilbert Research Topics

Disease

35	Fibrosis (Cirrhosis) 03/2021 - 06/2002
34	Diabetic Nephropathies (Diabetic Nephropathy) 03/2021 - 10/2001
20	Type 2 Diabetes Mellitus (MODY) 10/2021 - 06/2002
19	Hypertension (High Blood Pressure) 03/2021 - 06/2002
16	Proteinuria 03/2021 - 07/2002
15	Heart Failure 09/2022 - 08/2003
13	Chronic Renal Insufficiency 01/2019 - 05/2009
13	Albuminuria 12/2013 - 01/2003
11	Hypertrophy 01/2020 - 08/2003
11	Myocardial Infarction 01/2020 - 08/2003
7	Kidney Diseases (Kidney Disease) 03/2021 - 10/2004
6	Hypoxia (Hypoxemia) 01/2021 - 05/2002
6	Coronary Artery Disease (Coronary Atherosclerosis) 01/2021 - 05/2010
6	Diabetes Mellitus 01/2021 - 11/2003
4	Stroke (Strokes) 01/2020 - 03/2009
4	Infarction (Infarctions) 01/2020 - 08/2003
4	Inflammation (Inflammations) 01/2016 - 01/2007
4	Body Weight (Weight, Body) 01/2015 - 03/2003
4	Diabetic Cardiomyopathies 05/2012 - 11/2007
3	Isolated Systolic Hypertension 01/2017 - 05/2009
3	Heart Diseases (Heart Disease) 01/2017 - 02/2005
3	Glycosuria 01/2016 - 10/2014
3	Myocardial Ischemia (Ischemic Heart Diseases) 05/2014 - 04/2006
3	Hyperglycemia 01/2012 - 02/2003
3	Glomerulonephritis 09/2011 - 01/2008
3	Neoplasms (Cancer) 07/2011 - 10/2003
3	Retinopathy of Prematurity (Retrolental Fibroplasia) 04/2006 - 03/2003
2	Hyperoxia 02/2021 - 03/2003
2	Anemia 02/2021 - 01/2020
2	Acute Kidney Injury (Acute Renal Failure) 02/2021 - 01/2019
2	Ventricular Remodeling 01/2020 - 05/2010
2	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2018 - 09/2003
2	Focal Segmental Glomerulosclerosis (Glomerulosclerosis, Focal) 01/2017 - 07/2007
2	Diabetic Retinopathy (Retinopathy, Diabetic) 01/2016 - 08/2007

Drug/Important Bio-Agent (IBA)

19	Glucose (Dextrose)FDA LinkGeneric 09/2022 - 06/2002
15	SodiumIBA 09/2022 - 06/2002
14	Transforming Growth Factor beta (TGF-beta)IBA 05/2010 - 01/2002
13	Messenger RNA (mRNA)IBA 03/2021 - 05/2002
13	Proteins (Proteins, Gene)FDA Link 01/2020 - 05/2002
13	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2017 - 10/2001
9	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2020 - 05/2002
9	CollagenIBA 10/2013 - 10/2001
8	empagliflozinIBA 10/2021 - 02/2019
8	Streptozocin (Streptozotocin)FDA Link 01/2018 - 06/2002
8	tranilastIBA 12/2013 - 01/2003
7	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 01/2018 - 12/2008
6	Sirtuin 1IBA 03/2021 - 04/2015
6	CreatinineIBA 01/2017 - 01/2004
5	Angiotensin Receptors (Angiotensin II Receptor)IBA 03/2021 - 06/2002
5	Sodium-Glucose Transporter 2 InhibitorsIBA 01/2020 - 04/2014
5	Angiotensin Receptor AntagonistsIBA 01/2018 - 05/2009
5	Protein Isoforms (Isoforms)IBA 09/2011 - 07/2003
5	ruboxistaurinIBA 06/2009 - 08/2005
4	EnzymesIBA 03/2021 - 06/2009
4	Biomarkers (Surrogate Marker)IBA 01/2021 - 06/2014
4	CytokinesIBA 10/2018 - 10/2001
4	CanagliflozinIBA 04/2017 - 10/2014
4	Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA 01/2013 - 05/2002
4	Platelet-Derived Growth FactorIBA 01/2012 - 07/2003
4	nephrinIBA 01/2012 - 07/2002
4	Protein Kinase CIBA 09/2011 - 08/2005
4	Protein Kinase C betaIBA 06/2009 - 02/2003
3	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 03/2021 - 05/2009
3	Oxygen (Dioxygen)IBA 02/2021 - 03/2003
3	DiureticsIBA 01/2020 - 05/2009
3	Transforming Growth Factors (Transforming Growth Factor)IBA 10/2018 - 01/2012
3	dapagliflozinIBA 01/2018 - 10/2014
3	Insulin Glargine (Lantus)FDA Link 01/2018 - 07/2014
3	SymportersIBA 04/2017 - 12/2014
3	AlbuminsIBA 01/2017 - 06/2002
3	Retinaldehyde (Retinal)IBA 01/2016 - 03/2003
3	Calcium Channel Blockers (Blockers, Calcium Channel)IBA 01/2016 - 05/2009
3	Collagen Type IV (Type IV Collagen)IBA 01/2015 - 01/2008
3	Blood Glucose (Blood Sugar)IBA 10/2014 - 01/2003
3	FT011IBA 09/2013 - 01/2012
3	Angiotensin IIIBA 08/2011 - 06/2002
3	Epidermal Growth Factor (EGF)IBA 08/2011 - 01/2002
3	1,4-dihydropyridine (dihydropyridine)IBA 07/2011 - 05/2009
3	Dietary SodiumIBA 05/2010 - 06/2002
3	ReninIBA 03/2009 - 02/2003
3	OsteopontinIBA 12/2008 - 06/2002
3	Transforming Growth Factor beta1 (TGF beta 1)IBA 11/2007 - 02/2005
3	ChemokinesIBA 11/2007 - 03/2006
3	anthranilic acid (anthranilate)IBA 02/2005 - 01/2003
3	Peptides (Polypeptides)IBA 11/2004 - 07/2003
3	urotensin IIIBA 11/2004 - 01/2003
2	RNA (Ribonucleic Acid)IBA 03/2021 - 12/2006
2	Enalapril FDA LinkGeneric 03/2021 - 07/2016
2	SRT3025IBA 03/2021 - 01/2017
2	Erythropoietin FDA Link 01/2020 - 01/2020
2	Glycated Hemoglobin (Glycosylated Hemoglobin)IBA 11/2019 - 05/2014
2	Antihypertensive Agents (Antihypertensives)IBA 01/2017 - 07/2011
2	Conditioned Culture MediaIBA 07/2016 - 01/2015
2	LipidsIBA 01/2016 - 05/2010

Therapy/Procedure

27	Therapeutics 03/2021 - 07/2002
5	Nephrectomy 03/2021 - 07/2003
4	Drug Therapy (Chemotherapy) 05/2015 - 01/2003
2	Hemodilution 02/2021 - 01/2020
2	Ligation 01/2020 - 05/2010
2	Glycemic Control 06/2016 - 04/2014